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The Mania symbiote was cloned from a piece of the original Venom symbiote's tongue that was obtained by the Ararat Corporation, intended to facilitate Bob's goal of exterminating all life on Earth. Engineered in the the Ararat Corporation's Mesa Verde Laboratory in New Mexico, the symbiote clone initially refused to bond to any of the test subjects offered to it as hosts, instead opting to brutally kill them -- not to devour them, but out of sadistic enjoyment. However, when presented with a choice between two prospective hosts — an elderly mental patient named Alfonse Poina and a prison inmate named Eric Moody, sentenced for killing six men — the symbiote attacked both. When Moody managed to fight it off, the Venom clone bonded to Poina, mocking Moody over having been raped in prison — memories it gleaned from being in contact with him - before implicitly raping and killing him.